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(Z-Asp-Glu-Val-Asp)2-Rhodamine 110

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

(Z-Asp-Glu-Val-Asp)2-Rhodamine 110, a highly sensitive and photostable fluorogenic substrate, is used to determine intracellular caspase-3 activity. Fluorophore Rhodamine 110 (R110) can be detected at an emission wavelength of 535 nm using an excitation wavelength of 485 nm. As with (H-Asp-Glu-Val-Asp)2-Rhodamine 110, the fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy.

Category

Others

Catalog number

BAT-015344

CAS number

223538-61-2

Molecular Formula

C72H78N10O27

Molecular Weight

1515.46

Specification

IUPAC Name

(4S)-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[6'-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid

Synonyms

(Z-DEVD)2-Rhodamine 110; 4,4'-[9-(2-Carboxyphenyl)xanthylium-3,6-diyl]bis[N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-L-alpha-asparagine inner salt; (5S,8S,11S,14S,5'S,8'S,11'S,14'S)-14,14'-[(3-Oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diyl)dicarbamoyl]bis[8-(2-carboxyethyl)-5-(carboxymethyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid]; (Z-DEVD)2-Rh 110

Appearance

Orange Lyophilized Powder

Purity

95%

Density

1.5±0.1 g/cm3

Boiling Point

1782.2±65.0°C at 760 mmHg

Storage

Store at -20°C

Solubility

Soluble in Acetic Acid

InChI

InChI=1S/C72H78N10O27/c1-35(2)59(81-61(95)45(23-25-53(83)84)75-65(99)49(31-57(91)92)79-70(104)106-33-37-13-7-5-8-14-37)67(101)77-47(29-55(87)88)63(97)73-39-19-21-43-51(27-39)108-52-28-40(20-22-44(52)72(43)42-18-12-11-17-41(42)69(103)109-72)74-64(98)48(30-56(89)90)78-68(102)60(36(3)4)82-62(96)46(24-26-54(85)86)76-66(100)50(32-58(93)94)80-71(105)107-34-38-15-9-6-10-16-38/h5-22,27-28,35-36,45-50,59-60H,23-26,29-34H2,1-4H3,(H,73,97)(H,74,98)(H,75,99)(H,76,100)(H,77,101)(H,78,102)(H,79,104)(H,80,105)(H,81,95)(H,82,96)(H,83,84)(H,85,86)(H,87,88)(H,89,90)(H,91,92)(H,93,94)/t45-,46-,47-,48-,49-,50-,59-,60-/m0/s1

InChI Key

MRLMIVOGDRELQK-DLODMIPSSA-N

Canonical SMILES

CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)OCC5=CC=CC=C5)C6=CC=CC=C6C(=O)O3)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)OCC7=CC=CC=C7