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Z-VRPR-FMK trifluoroacetate salt

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Z-VRPR-FMK trifluoroacetate salt is an irreversible and cell-permeable MALT1 inhibitor. Z-VRPR-FMK dose-dependently inhibits T cell activation-induced cleavage of Bcl-10. Z-VRPR-FMK reduces NF-κB-dependent gene expression in lymphocytes.

Category

Peptide Inhibitors

Catalog number

BAT-010228

Molecular Formula

C31H49FN10O6.CF3CO2H

Molecular Weight

790.81

Specification

IUPAC Name

benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-[[6-(diaminomethylideneamino)-1-fluoro-2-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate; 2,2,2-trifluoroacetic acid

Synonyms

Z-Val-Arg-Pro-DL-Arg-FMK

Related CAS

1381885-28-4 (free base)

Appearance

Solid Powder

Purity

>90%

Sequence

Cbz-Val-Arg-Pro-DL-Arg-CH2F.TFA

Storage

Store at -20°C

InChI

InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1

InChI Key

WIPHXOQUHDJLCU-WTJMUODPSA-N

Canonical SMILES

CC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O